Sodium Bicarbonate → HCID 67043177, compound

HRID 1626028Notes

Reaction equation

HRID 1626028 reaction equation
C(=O)([O-])O.[Na+:5].[Cl:6][C:7]1[CH:44]=[CH:43][C:10]2[N:11]([C:24](=[O:42])[C:25]3[CH:30]=[CH:29][C:28]([NH:31][C:32](=[O:40])[C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=4[CH3:39])=[CH:27][C:26]=3[CH3:41])[CH2:12][CH2:13][CH2:14][CH:15]([CH:16]([CH2:20][C:21]([O-:23])=[O:22])[C:17]([O-:19])=[O:18])[C:9]=2[CH:8]=1>CO>[Cl:6][C:7]1[CH:44]=[CH:43][C:10]2[N:11]([C:24](=[O:42])[C:25]3[CH:30]=[CH:29][C:28]([NH:31][C:32](=[O:40])[C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=4[CH3:39])=[CH:27][C:26]=3[CH3:41])[CH2:12][CH2:13][CH2:14][CH:15]([CH:16]([CH2:20][C:21]([O-:23])=[O:22])[C:17]([O-:19])=[O:18])[C:9]=2[CH:8]=1.[Na+:5].[Na+:5]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 86652150HCID 86652150, compound

Product 1

HCID 67043177HCID 67043177, compoundYield 177.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A sodium hydrogen carbonate (46 mg, 0.55 mmol) aqueous solution (2 ml) was added to a methanol solution (2 ml) of {7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}succinate (0.30 g, 0.55 mmol), and the mixture was stirred at room temperature for 1 hour. Methanol was distilled off under reduced pressure at about 30° C. The resulting solution was freeze-dried to obtain 0.29 g (94%) of sodium {7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}succinate as amorphous.

Workup

  1. distillationMethanol was distilled off under reduced pressure at about 30° C
  2. customThe resulting solution was freeze-dried

Sources & evidence

ORD record
ord-a9504217cca74cdeac96d9f47f5745af
Source dataset
uspto-grants-2014_07
Patent number
US08785386B2

Reaction notes

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