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HRID 1626079作成日：2026年10月25日

tert-Butylsulfinamide, (S)-(-)- → (NE,S)-N-[1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene]-2-methylpropane-2-sulfinamide

https://huagongshe.com/reaction/1626079

反応式

関与物質

役割名称HCID仕込み量
反応物tert-Butylsulfinamide, (S)-(-)-HCID 11355477—
反応物1-(5-Bromo-2-fluorophenyl)-2,2-difluoroethanoneHCID 54857833—
生成物(NE,S)-N-[1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene]-2-methylpropane-2-sulfinamideHCID 8918362178%

反応手順

Starting from 1-(5-bromo-2-fluorophenyl)-2,2-difluoroethanone and (S)-(−)-2-methyl-2-propanesulfinamide, the (S,E)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene)-2-methylpropane-2-sulfinamide (14.49 g, 78.0% yield) was obtained as a yellow oil. MS (ISP): m/z=355.9 [M+H]+ and 357.9 [M+2+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08785436B2
出典データセットuspto-grants-2014_07
ORD IDord-84ca13c3146542238787518c75858b76
出典メモuspto-grants-2014_07