Iodine → HCID 87410559, compound

HRID 1626239Notes

Reaction equation

HRID 1626239 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]=2[CH:4]=1.[I:19]I>C(Cl)(Cl)Cl>[I-:19].[F:18][C:2]([F:1])([F:17])[C:3]1[CH:16]=[CH:15][C:14]2[C:5](=[N:6][C:7]3[C:12]([S+:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=1

Participants

4

Reactant 2

HCID 807IodineHCID 708210H-Phenothiazine, 2-(trifluoromethyl)-

Product 1

HCID 87410559HCID 87410559, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Commercially available 2-Trifluoromethylphenothiazine (1.14 g, 4.28 mmol) was dissolved in CHCl3 (20 mL) and a solution of I2 (3.25 g, 12.84 mmol) in CHCl3 (120 mL) was added. The mixture was warmed at 55° C. to 60° C. until the SM was consumed (by TLC). The reaction mixture was allowed to cool to RT and the solvent was evaporated. The residue was stirred in Et2O, filtered off and washed with Et2O until the filtrate was colorless. The intermediate was used without further purification.

Workup

  1. temperatureThe mixture was warmed at 55° C. to 60° C. until the SM
  2. customwas consumed (by TLC)
  3. customthe solvent was evaporated
  4. filtrationfiltered off
  5. washwashed with Et2O until the filtrate
  6. customThe intermediate was used without further purification

Sources & evidence

ORD record
ord-f6f2d20709bd42318fa48ed09c06fe02
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

Loading…