Trifluoroacetic acid → HCID 178495925, compound

HRID 1626247Notes

Reaction equation

HRID 1626247 reaction equation
[I-].[CH3:2][O:3][CH2:4][CH2:5][N:6]([CH2:34][CH2:35][O:36][CH3:37])[C:7]1[CH:8]=[CH:9][C:10]2[C:19]([CH:20]=1)=[S+:18][C:17]1[C:12](=[CH:13][CH:14]=[C:15]([N:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[CH:16]=1)[N:11]=2.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>C(Cl)Cl>[CH3:2][O:3][CH2:4][CH2:5][N:6]([CH2:34][CH2:35][O:36][CH3:37])[C:7]1[CH:8]=[CH:9][C:10]2[C:19]([CH:20]=1)=[S+:18][C:17]1[C:12](=[CH:13][CH:14]=[C:15]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[CH:16]=1)[N:11]=2.[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178495926HCID 178495926, compound

Product 1

HCID 178495925HCID 178495925, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(Bis(2-methoxyethyl)amino)-7-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenothiazin-5-ium iodide was dissolved in CH2Cl2 and trifluoroacetic acid (1:1 mixture) and heated at 50° C. for 2 to 4 h. The mixture was allowed to cool to RT and the solvent was evaporated to give a residue, which was purified by flash silica gel chromatography. Isolated 15 mg of a dark blue solid as the desired product.

Workup

  1. customthe solvent was evaporated
  2. customto give a residue, which
  3. customwas purified by flash silica gel chromatography

Sources & evidence

ORD record
ord-d87fce4d6f8d4589a43ec5a7ee5a014e
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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