Trifluoroacetic acid → HCID 178463829, compound

HRID 1626249Notes

Reaction equation

HRID 1626249 reaction equation
[I-].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]3[C:26](=[CH:27][CH:28]=2)[N:25]=[C:24]2[C:19]([CH:20]=[C:21]([N:30]([CH2:33][CH3:34])[CH2:31][CH3:32])[CH:22]=[C:23]2[Cl:29])=[S+:18]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>C(Cl)Cl>[F:35][C:36]([F:41])([F:40])[C:37]([O-:39])=[O:38].[Cl:29][C:23]1[C:24]2[C:19](=[S+:18][C:17]3[C:26]([N:25]=2)=[CH:27][CH:28]=[C:15]([N:12]2[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]2)[CH:16]=3)[CH:20]=[C:21]([N:30]([CH2:33][CH3:34])[CH2:31][CH3:32])[CH:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178463830HCID 178463830, compound

Product 1

HCID 178463829HCID 178463829, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-chloro-3-(diethylamino)phenothiazin-5-ium iodide was dissolved in CH2Cl2 (4 mL) and trifluoroactic acid (4 mL) and heated at 70° C. overnight. The mixture was allowed to cool to RT and the solvent was evaporated to give a residue. The residue was purified by Prep TLC to give 2.2 mg of the desired product.

Workup

  1. customthe solvent was evaporated
  2. customto give a residue
  3. customThe residue was purified by Prep TLC

Sources & evidence

ORD record
ord-550339e9039b429b8402e9e332a83aaf
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

Loading…