Methanol → HCID 178452218, compound

HRID 1626251Notes

Reaction equation

HRID 1626251 reaction equation
[OH2:1].[I-:2].[I-].[I-].[I-].[F:6][C:7]([F:23])([F:22])[C:8]1[C:21]2[C:12](=[S+:13][C:14]3[C:19]([N:20]=2)=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1.FC(C1[C:41]2[C:32](=[S+][C:34]3[C:39]([N:40]=2)=CC=CC=3)C=CC=1)(F)F.F[C:43]([C:46]1[C:59]2C(=[S+]C3C(N=2)=CC=CC=3)C=C[CH:47]=1)(F)F.FC(C1[C:77]2C(=[S+]C3C([N:76]=2)=CC=CC=3)C=CC=1)(F)F.[C:78]([N:85]1[CH2:90][CH2:89][NH:88][CH2:87][CH2:86]1)([O:80][C:81]([CH3:84])([CH3:83])[CH3:82])=[O:79].C[OH:92]>>[I-:2].[C:78]([N:85]1[CH2:86][CH2:87][N:88]([C:10]2[C:9]([N:40]3[CH2:39][CH2:34][N:76]([C:77]([O:92][C:46]([CH3:43])([CH3:47])[CH3:59])=[O:1])[CH2:32][CH2:41]3)=[C:8]([C:7]([F:6])([F:22])[F:23])[C:21]3[C:12]([CH:11]=2)=[S+:13][C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:20]=3)[CH2:89][CH2:90]1)([O:80][C:81]([CH3:84])([CH3:83])[CH3:82])=[O:79]

Participants

4

Reactant 3

HCID 887MethanolHCID 143452tert-Butyl piperazine-1-carboxylateHCID 86667008HCID 86667008, compound

Product 1

HCID 178452218HCID 178452218, compound

Procedure

A solution of 1-trifluoromethylphenothiazin-5-ium tetraiodide hydrate (150 mg, 0.19 mmol) in methanol (10 mL) and 1-Boc-piperazine (93 mg, 0.5 mmol) was stirred for 4 h at room temperature. The resulting mixture was concentrated to dryness and purified by flash chromatography using the methanol-chloroform gradient to provide the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. custompurified by flash chromatography

Sources & evidence

ORD record
ord-48d7c06f9b5747b394d1a098c2c6051d
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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