Trifluoroacetic acid → HCID 178482609, compound

HRID 1626252Notes

Reaction equation

HRID 1626252 reaction equation
[I-].[CH3:2][N:3]([CH3:35])[C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]1[C:8]([CH:9]=[C:10]([N:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]3)[CH:11]=[C:12]1[C:18]([F:21])([F:20])[F:19])=[S+:7]2.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>ClCCl>[F:36][C:37]([F:42])([F:41])[C:38]([O-:40])=[O:39].[CH3:2][N:3]([CH3:35])[C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]1[C:8]([CH:9]=[C:10]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[CH:11]=[C:12]1[C:18]([F:20])([F:21])[F:19])=[S+:7]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178482610HCID 178482610, compound

Product 1

HCID 178482609HCID 178482609, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 7-(dimethylamino)-1-trifluoromethyl-3-(4-Boc-piperazin-1-yl)-phenothiazin-5-ium iodide (50 mg) in dichloromethane (5 mL) and trifluoroacetic acid (0.5 mL) was stirred for 2 h at room temperature. The resulting mixture was concentrated to dryness, rinsed out by toluene (3×10 mL) and dried under vacuum to provide the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. washrinsed out by toluene (3×10 mL)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-71e58811f5cc4e498c8ff6064bb9c0ad
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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