HCID 178436737, compound → HCID 178436733, compound

HRID 1626272Notes

Reaction equation

HRID 1626272 reaction equation
[I-:1].C([N:9]1[CH2:15][CH2:14][CH2:13][N:12]([C:16]2[CH:17]=[C:18]([CH2:36][CH3:37])[C:19]3[C:28]([CH:29]=2)=[S+:27][C:26]2[C:21](=[C:22]([CH3:35])[CH:23]=[C:24]([N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)[CH:25]=2)[N:20]=3)[CH2:11][CH2:10]1)(OC(C)(C)C)=O>ClCCl.FC(F)(F)C(O)=O>[I-:1].[N:12]1([C:16]2[CH:17]=[C:18]([CH2:36][CH3:37])[C:19]3[C:28]([CH:29]=2)=[S+:27][C:26]2[C:21](=[C:22]([CH3:35])[CH:23]=[C:24]([N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)[CH:25]=2)[N:20]=3)[CH2:13][CH2:14][CH2:15][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 1

HCID 178436737HCID 178436737, compound

Product 1

HCID 178436733HCID 178436733, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 3-(4-Boc-1,4-diazepan-1-yl)-1-ethyl-9-methyl-7-(pyrrolidin-1-yl)-phenothiazin-5-ium iodide (65 mg, 0.01 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (1.0 mL) was stirred for 3 h at 50° C. The resulting mixture was washed by toluene (2×5 mL), pentane (2×5 mL) and concentrated to dryness.

Workup

  1. washThe resulting mixture was washed by toluene (2×5 mL), pentane (2×5 mL)
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-84f6047f9e6340afb4e8afb8e8bcf1ce
Source dataset
uspto-grants-2014_07
Patent number
US08785434B2

Reaction notes

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