Potassium Carbonate → 1-(2,3-Dimethylphenyl)-4-(2-(oxiran-2-yl)ethyl)piperazine

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(2-bromoethyl)oxirane obtained in step 1 (0.70 g, 4.61 mmol) and potassium carbonate (1.91 g, 13.8 mmol) in acetone (10 ml), was added 1-(2,3-dimethylphenyl)piperazine hydrochloride (1.04 g, 4.61 mmol) at room temperature. The resulting reaction mixture was stirred at 65° C. for 16 hours. After the reaction complete, the reaction mixture thus obtained was filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to obtain the title compound (0.31 g). The compound was used for the next step without further purification.

Provenance & Evidence