Potassium Carbonate → 1-(2,3-Dimethylphenyl)-4-(2-(oxiran-2-yl)ethyl)piperazine

HRID 1626310Notes

Reaction equation

Br[CH2:2][CH2:3][CH:4]1[CH2:6][O:5]1.C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:14][C:15]1[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CC(C)=O>[CH3:14][C:15]1[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=1[N:22]1[CH2:23][CH2:24][N:25]([CH2:2][CH2:3][CH:4]2[CH2:6][O:5]2)[CH2:26][CH2:27]1

Participants

Conditions

Temperature: 65 °C

Procedure

To a mixture of 2-(2-bromoethyl)oxirane obtained in step 1 (0.70 g, 4.61 mmol) and potassium carbonate (1.91 g, 13.8 mmol) in acetone (10 ml), was added 1-(2,3-dimethylphenyl)piperazine hydrochloride (1.04 g, 4.61 mmol) at room temperature. The resulting reaction mixture was stirred at 65° C. for 16 hours. After the reaction complete, the reaction mixture thus obtained was filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to obtain the title compound (0.31 g). The compound was used for the next step without further purification.

Workup

customThe resulting reaction mixture
customAfter the reaction complete, the reaction mixture thus obtained
filtrationwas filtered through a plug of Celite
concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record: ord-62c4966968d34c2eb9600296798276e7
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785453B2

Reaction notes

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