Methylamine → 4-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-1-(methylamino)butan-2-ol

HRID 1626311Notes

Reaction equation

[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH:17]2[CH2:19][O:18]2)[CH2:11][CH2:10]1.[CH3:20][NH2:21]>C(O)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH:17]([OH:18])[CH2:19][NH:21][CH3:20])[CH2:11][CH2:10]1

Participants

Conditions

Temperature: 90 °C

Procedure

A mixture of 1-(2,3-dimethylphenyl)-4-(2-(oxiran-2-yl)ethyl)piperazine obtained in step 2 (0.10 g, 0.38 mmol) and methylamine (8.0 M) in ethanol (1.0 ml) was stirred at 90° C. for 20 hours. After the reaction complete, the resulting reaction mixture was concentrated under reduced pressure to obtain the title compound (0.10 g). The compound was used for the next step without further purification.

Workup

customAfter the reaction complete, the resulting reaction mixture
concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record: ord-614e1a2d1e0344629e52805dc7c532a2
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08785453B2

Reaction notes

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