2-Methylpiperazine → HCID 20099357, compound

Participants

Reaction Steps

650 mg (6.48 mmol) of 2-methylpiperazine, 800 mg (4.32 mmol) of 3-bromo-o-xylene, 50 mg (0.22 mmol) of palladium acetate, 110 mg (0.17 mmol) of BINAP and 830 mg (8.65 mmol) of sodium tert-butoxide in dry toluene (8.6 mL) were heated at 110° C. for 14 hours. After cooling, the resulting reaction mixture was quenched with water and extracted with ethyl acetate. The ethyl acetate phase was concentrated. The residue was purified by chromatography to give the title compound as a yellow semi solid.

Provenance & Evidence