HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(3,5-Dichloro-pyridin-2-YL)-ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 67287275 | HCID 67287275 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3,5-Dichloro-pyridin-2-YL)-ethylamine | HCID 23068289 | 100% |
Reaction Steps
Tert-butyl 2-(3,5-dichloropyridin-2-yl)ethylcarbamate (50 mg, 0.17 mmol) was diluted with DCM (500 uL) followed by the addition of TFA (500 μl). After stirring for 2 hours, the reaction was concentrated and placed under vacuum to yield the desired compound (32 mg, 0.17 mmol, 98% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785445B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-c27ff43ad9ef4678b90d8450ff1c384c |
| Source note | uspto-grants-2014_07 |