Trifluoroacetic acid → 2-(3,5-Dichloropyridin-2-yl)ethan-1-amine

HRID 1626476Notes

Reaction equation

HRID 1626476 reaction equation
[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][NH2:11])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67287275HCID 67287275, compound

Product 1

HCID 230682892-(3,5-Dichloropyridin-2-yl)ethan-1-amineYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 2-(3,5-dichloropyridin-2-yl)ethylcarbamate (50 mg, 0.17 mmol) was diluted with DCM (500 uL) followed by the addition of TFA (500 μl). After stirring for 2 hours, the reaction was concentrated and placed under vacuum to yield the desired compound (32 mg, 0.17 mmol, 98% yield).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-c27ff43ad9ef4678b90d8450ff1c384c
Source dataset
uspto-grants-2014_07
Patent number
US08785445B2

Reaction notes

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