Sodium Hydroxide → HCID 86664397, compound

HRID 1626492Notes

Reaction equation

HRID 1626492 reaction equation
[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:14].[Na+]>>[O:8]=[CH:9][CH:10]([NH:11][C:7](=[O:14])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH:12]=[O:13]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 155551412-Phenyl-1,3-oxazole-4-carbaldehyde

Product 1

HCID 86664397HCID 86664397, compoundYield 88%

Procedure

2-phenyloxazole-4-carbaldehyde (5.0 g, 28.9 mmol) and 2.0 M aqueous sodium hydroxide solution (50 ml) were heated to 70° C. in a 250 mL Erlenmeyer flask until dissolved. Some insoluble dark material remained which was removed by filtration. The reaction was cooled in an ice bath and acidified (sulfuric acid) with swirling. The resulting solid was collected by filtration, washed with water, and dried under vacuum to provide the title compound (4.85 g, 88%).

Workup

  1. dissolutionuntil dissolved
  2. customwas removed by filtration
  3. temperatureThe reaction was cooled in an ice bath
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with water
  6. customdried under vacuum

Sources & evidence

ORD record
ord-978942b852874e60a8c38819233fe081
Source dataset
uspto-grants-2014_07
Patent number
US08785445B2

Reaction notes

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