4-Fluoroaniline → (S)-1-(4-fluorophenyl)-3-(4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

HRID 1626566Notes

Reaction equation

HRID 1626566 reaction equation
[CH3:1][N:2]1[CH2:10][C:9]2[C:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][C@@H:12]3[CH3:17])=[N:7][C:6]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:25](=O)[O:26]C4C=CC=CC=4)=[CH:20][CH:19]=3)=[N:5][C:4]=2[CH2:3]1.[F:34][C:35]1[CH:41]=[CH:40][C:38]([NH2:39])=[CH:37][CH:36]=1>>[F:34][C:35]1[CH:41]=[CH:40][C:38]([NH:39][C:25]([NH:24][C:21]2[CH:22]=[CH:23][C:18]([C:6]3[N:7]=[C:8]([N:11]4[CH2:16][CH2:15][O:14][CH2:13][C@@H:12]4[CH3:17])[C:9]4[CH2:10][N:2]([CH3:1])[CH2:3][C:4]=4[N:5]=3)=[CH:19][CH:20]=2)=[O:26])=[CH:37][CH:36]=1

Participants

3

Procedure

Method as described for example 51 using intermediate 10 and 4-fluoroaniline as starting materials. Purified by prep. LCMS (high pH).

Workup

  1. customPurified by prep

Sources & evidence

ORD record
ord-6871a92f2b9a47c79a80086e54a485f5
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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