3-Methoxypropylamine → (S)-1-(3-methoxypropyl)-3-(4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea
Reaction equation
[CH3:1][N:2]1[CH2:10][C:9]2[C:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][C@@H:12]3[CH3:17])=[N:7][C:6]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:33])OC4C=CC=CC=4)=[CH:20][CH:19]=3)=[N:5][C:4]=2[CH2:3]1.[CH3:34][O:35][CH2:36][CH2:37][CH2:38][NH2:39]>>[CH3:34][O:35][CH2:36][CH2:37][CH2:38][NH:39][C:25]([NH:24][C:21]1[CH:20]=[CH:19][C:18]([C:6]2[N:7]=[C:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][C@@H:12]3[CH3:17])[C:9]3[CH2:10][N:2]([CH3:1])[CH2:3][C:4]=3[N:5]=2)=[CH:23][CH:22]=1)=[O:33]Participants
3
Procedure
Method as described for example 51 using intermediate 10 and 3-methoxypropylamine as starting materials. Purified by prep. LCMS (high pH).
Workup
- customPurified by prep
Sources & evidence
- ORD record
- ord-470cf0918483407396d12b03fd8400b6
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08785457B2
Reaction notes
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