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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1626580Generated: October 31, 2026

Hydrochloric Acid → HCID 66687926, compound

https://huagongshe.com/reaction/1626580

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethanolHCID 887—
ReactantHCID 66687468HCID 66687468—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 66687926HCID 66687926100%

Reaction Steps

(S)-tert-butyl 2-(4-(3-ethylureido)-3-fluorophenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (510 mg, 1.02 mmol) was stirred in a solution of 4M HCl in Dioxane (10 ml), and methanol (3 ml) until analysis by LCMS indicated reaction was complete. Solvent was removed in vacuo to afford a light brown solid (450 mg, 1.02 mmol, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08785457B2
Source datasetuspto-grants-2014_07
ORD IDord-fd5a55b70095485d83ae5d7968ca355a
Source noteuspto-grants-2014_07