Hydrochloric Acid → HCID 66687926, compound

HRID 1626580Notes

Reaction equation

HRID 1626580 reaction equation
[CH2:1]([NH:3][C:4](=[O:36])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][C@@H:29]3[CH3:34])[C:15]3[CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][C:16]=3[N:17]=2)=[CH:8][C:7]=1[F:35])[CH3:2].[ClH:37].CO>O1CCOCC1>[ClH:37].[CH2:1]([NH:3][C:4]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][C@@H:29]3[CH3:34])[C:15]3[CH2:20][NH:19][CH2:18][C:16]=3[N:17]=2)=[CH:8][C:7]=1[F:35])=[O:36])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 66687468HCID 66687468, compound

Product 1

HCID 66687926HCID 66687926, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-tert-butyl 2-(4-(3-ethylureido)-3-fluorophenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (510 mg, 1.02 mmol) was stirred in a solution of 4M HCl in Dioxane (10 ml), and methanol (3 ml) until analysis by LCMS indicated reaction was complete. Solvent was removed in vacuo to afford a light brown solid (450 mg, 1.02 mmol, 100%).

Workup

  1. customreaction
  2. customSolvent was removed in vacuo

Sources & evidence

ORD record
ord-fd5a55b70095485d83ae5d7968ca355a
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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