Ethyl isocyanate → HCID 66678784, compound

HRID 1626620Notes

Reaction equation

HRID 1626620 reaction equation
[F:1][C:2]1[CH:8]=[C:7]([C:9]2[N:10]=[C:11]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][C@@H:21]3[CH3:26])[C:12]3[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][C:13]=3[N:14]=2)[C:6]([F:27])=[CH:5][C:3]=1[NH2:4].[CH2:28]([N:30]=[C:31]=[O:32])[CH3:29]>>[F:1][C:2]1[CH:8]=[C:7]([C:9]2[N:10]=[C:11]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][C@@H:21]3[CH3:26])[C:12]3[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][C:13]=3[N:14]=2)[C:6]([F:27])=[CH:5][C:3]=1[NH:4][C:31]([NH:30][CH2:28][CH3:29])=[O:32]

Participants

3

Reactant 2

HCID 8022Ethyl isocyanateHCID 66687442HCID 66687442, compound

Product 1

HCID 66678784HCID 66678784, compoundYield 11%

Procedure

Method as example 85 using (S)-2,5-difluoro-4-(7-methyl-4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline and ethyl isocyanate as starting material. The solvent was removed in vacuo and purified twice by flash chromatography using 0-20% DCM/MeOH as eluent yielding the title compound (6.2 mg, 0.013 mmol, 11%).

Workup

  1. customThe solvent was removed in vacuo
  2. custompurified twice by flash chromatography

Sources & evidence

ORD record
ord-362fc27c59f2430c807dfa8e122da136
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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