2-Oxo-1-pyrrolidinepropanoic acid → HCID 66679195, compound

HRID 1626645Notes

Reaction equation

HRID 1626645 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]([OH:11])=O.[CH:12]1([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[N:26]=[C:27]([N:34]4[CH2:39][CH2:38][O:37][CH2:36][C@@H:35]4[CH3:40])[C:28]4[CH2:33][NH:32][CH2:31][C:29]=4[N:30]=3)=[CH:21][CH:20]=2)=[O:17])[CH2:14][CH2:13]1>>[CH:12]1([NH:15][C:16]([NH:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[N:26]=[C:27]([N:34]4[CH2:39][CH2:38][O:37][CH2:36][C@@H:35]4[CH3:40])[C:28]4[CH2:33][N:32]([C:9](=[O:11])[CH2:8][CH2:7][N:3]5[CH2:4][CH2:5][CH2:6][C:2]5=[O:1])[CH2:31][C:29]=4[N:30]=3)=[CH:23][CH:24]=2)=[O:17])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 31466882-Oxo-1-pyrrolidinepropanoic acidHCID 46894114(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Product 1

HCID 66679195HCID 66679195, compound

Procedure

Method as example 127 using 3-(2-oxopyrrolidin-1-yl)propanoic acid and (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) as starting materials. Purified by prep HPLC at low pH to afford a white solid. (35.3 mg, 0.066 mmol, 29%).

Workup

  1. customPurified by prep HPLC at low pH
  2. customto afford a white solid

Sources & evidence

ORD record
ord-d43bc19dc92744bea8792bf800478fc6
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

Loading…