Hydrochloric Acid → 5-Chloro-2-{[4-({[3-(furan-3-yl)phenyl]carbonyl}amino)butanoyl]amino}benzoic acid

Participants

Reaction Conditions

Reaction Steps

1.22 g (2.8 mmol) of methyl 5-chloro-2-{[4-({[3-(furan-3-yl)phenyl]carbonyl}amino)butanoyl]amino}benzoate was dissolved in 12 mL of tetrahydrofuran (THF). 1N aqueous sodium hydroxide was added at room temperature, and the mixture was stirred at 50° C. for 1.5 hours. After cooling the mixture, 1N hydrochloric acid was added to acidify the reaction mixture, and the solvent was distilled off under reduced pressure. Thereafter, water was added to the residue. Solids were collected by filtration, followed by washing with water, thereby giving 1.07 g of the target 5-chloro-2-{[4-({[3-(furan-3-yl)phenyl]carbonyl}amino)butanoyl]amino}benzoic acid (yield: 91%).

Provenance & Evidence