Sodium Hydroxide → HCID 66680174, compound

Participants

Reaction Steps

20 mL of THF and 1.6 mL of 1N aqueous sodium hydroxide solution were added to 360 mg (0.86 mmol) of methyl 5-chloro-2-({[3-(isoquinolin-4-yl)phenyl]carbonyl}amino)benzoate, and the mixture was stirred at room temperature for one day. THF was distilled off under reduced pressure and water-washing was performed by adding water, thereby giving 360 mg of the target sodium 5-chloro-2-({[3-(isoquinolin-4-yl)phenyl]carbonyl}amino)benzoate (yield: 98%).

Provenance & Evidence