Sodium Hydroxide → HCID 66680174, compound

HRID 1626754Notes

Reaction equation

HRID 1626754 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([NH:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:26]=[N:25][CH:24]=3)[CH:18]=2)=[O:16])=[C:8]([CH:13]=1)[C:9]([O:11]C)=[O:10]>C1COCC1>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([NH:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:26]=[N:25][CH:24]=3)[CH:18]=2)=[O:16])=[C:8]([CH:13]=1)[C:9]([O-:11])=[O:10].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66680851HCID 66680851, compound

Product 1

HCID 66680174HCID 66680174, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

20 mL of THF and 1.6 mL of 1N aqueous sodium hydroxide solution were added to 360 mg (0.86 mmol) of methyl 5-chloro-2-({[3-(isoquinolin-4-yl)phenyl]carbonyl}amino)benzoate, and the mixture was stirred at room temperature for one day. THF was distilled off under reduced pressure and water-washing was performed by adding water, thereby giving 360 mg of the target sodium 5-chloro-2-({[3-(isoquinolin-4-yl)phenyl]carbonyl}amino)benzoate (yield: 98%).

Workup

  1. distillationTHF was distilled off under reduced pressure and water-
  2. washwashing
  3. additionby adding water

Sources & evidence

ORD record
ord-09f3a79f15e24b4797a37809c61542bc
Source dataset
uspto-grants-2014_07
Patent number
US08785473B2

Reaction notes

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