Methyl 2-amino-5-chlorobenzoate → HCID 66680793, compound

HRID 1626768Notes

Reaction equation

HRID 1626768 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:18]=1[C:19]([O:21]C)=[O:20]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:17]([NH:16][C:13]([C:11]2[S:12][C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)=[O:15])=[C:18]([CH:23]=1)[C:19]([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 78878Methyl 2-amino-5-chlorobenzoateHCID 18734015-(4-Fluorophenyl)thiophene-2-carboxylic acid

Product 1

HCID 66680793HCID 66680793, compoundYield 47%

Procedure

Using the same method as in Example 3-(i), methyl 5-chloro-2-({[5-(4-fluorophenyl)thiophen-2-yl]carbonyl}amino)benzoate was obtained using 5-(4-fluorophenyl)thiophen-2-carboxylic acid and methyl 2-amino-5-chlorobenzoate. Thereafter, using the same method as in Example 3-(ii), the target 5-chloro-2-({[5-(4-fluorophenyl)thiophen-2-yl]carbonyl}amino)benzoic acid was obtained (yield: 47%).

Sources & evidence

ORD record
ord-5e9fc09de4824a1a8dcd9c7cca32fb85
Source dataset
uspto-grants-2014_07
Patent number
US08785473B2

Reaction notes

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