(4-Bromophenyl)boronic acid → Ethyl 6-(4-bromophenyl)nicotinate

HRID 1626802노트

반응식

HRID 1626802 반응식
Br[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([C:2]2[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=2)=[CH:16][CH:15]=1

참가 물질

3

반응물 2

HCID 79599(4-Bromophenyl)boronic acidHCID 14784668Ethyl 6-bromonicotinate

생성물 1

HCID 68193233Ethyl 6-(4-bromophenyl)nicotinate수율 98%

실험 절차

In accordance with Example 11-(1), but using ethyl 6-bromonicotinate instead of 4-bromobenzylbromide, and 4-bromophenylboronic acid instead of [3-(hydroxymethyl)phenyl]boronic acid, the title compound (yield 98%) was afforded as a white solid.

출처 및 근거

ORD 기록
ord-ed36ab0287a34f0ca47e1ec93bfc6434
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785462B2

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