HRID1626805

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2725036

tert-Butyl glycinate--hydrogen chloride (1/1)

C6H14ClNO2

结构：Cc1nc(CC2CCN(C(=O)OC(C)(C)C)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1

HCID58257700

未命名化合物

结构：Cc1nc(CC2CCN(c3ccc(-c4ccc(CO)cc4)cc3)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1

HCID68193244

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(CC2CCNCC2)nc(C(=O)NCC(=O)OC(C)(C)C)c1OCc1ccccc1.Cl

HCID86670085

未命名化合物

收率 72%

PROCEDURE

实验过程

In accordance with Examples 1-(11) and 1-(7), but using tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate obtained in Example 1-(6) instead of tert-butyl 5-(benzyloxy)-2-{(1-[4′-(hydroxymethyl)biphenyl-4-yl]piperidin-4-yl}methyl)-6-methylpyrimidine-4-carboxylate, and glycine tert-butyl ester hydrochloride instead of glycine ethyl ester hydrochloride, the title compound (yield 72%) was afforded as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53283ad676a04595a7b92b173d482e38
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08785462B2
来源说明: uspto-grants-2014_07

反应 SMILES

[CH2:1]([O:8][C:9]1[C:10]([C:30](OC(C)(C)C)=[O:31])=[N:11][C:12]([CH2:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[N:13][C:14]=1[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC1[C:46]([C:73]([O:75][C:76]([CH3:79])([CH3:78])[CH3:77])=[O:74])=[N:47]C(CC2CCN(C3C=CC(C4C=CC(CO)=CC=4)=CC=3)CC2)=NC=1C)C1C=CC=CC=1.[ClH:80].C(OC(=O)CN)(C)(C)C>>[ClH:80].[C:76]([O:75][C:73](=[O:74])[CH2:46][NH:47][C:30]([C:10]1[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:14]([CH3:15])[N:13]=[C:12]([CH2:16][CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)[N:11]=1)=[O:31])([CH3:79])([CH3:78])[CH3:77]