Glycine tert-butyl ester hydrochloride → Tert-butyl ({[5-(benzyloxy)-6-methyl-2-(piperidin-4-ylmethyl)pyrimidin-4-yl]carbonyl}amino)acetate hydrochloride

Participants

Reaction Steps

In accordance with Examples 1-(11) and 1-(7), but using tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate obtained in Example 1-(6) instead of tert-butyl 5-(benzyloxy)-2-{(1-[4′-(hydroxymethyl)biphenyl-4-yl]piperidin-4-yl}methyl)-6-methylpyrimidine-4-carboxylate, and glycine tert-butyl ester hydrochloride instead of glycine ethyl ester hydrochloride, the title compound (yield 72%) was afforded as a white solid.

Provenance & Evidence