HRID1626806

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68193210

未命名化合物

结构：Cc1nc(CC2CCNCC2)nc(C(=O)NCC(=O)OC(C)(C)C)c1OCc1ccccc1.Cl

HCID86670085

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1ccccc1Cc1ccc(N2CCC(Cc3nc(C)c(OCc4ccccc4)c(C(=O)NCC(=O)OC(C)(C)C)n3)CC2)cc1

HCID68193257

未命名化合物

收率 72%

PROCEDURE

实验过程

In accordance with Example 1-(9), but using tert-butyl ({[5-(benzyloxy)-6-methyl-2-(piperidin-4-ylmethyl)pyrimidin-4-yl]carbonyl}amino)acetate hydrochloride instead of tert-butyl 5-(benzyloxy)-6-methyl-2-(piperidin-4-ylmethyl)pyrimidine-4-carboxylate hydrochloride, and ethyl 2-(4-bromobenzyl)benzoate instead of [(4′-bromobiphenyl-4-yl)methoxy](tert-butyl)dimethylsilane, the title compound (yield 72%) was afforded as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-874e7e09a35240f89f2919ade0d19d86
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08785462B2
来源说明: uspto-grants-2014_07

反应 SMILES

Cl.[CH2:2]([O:9][C:10]1[C:11]([C:24]([NH:26][CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])=[O:25])=[N:12][C:13]([CH2:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[N:14][C:15]=1[CH3:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[C:36]1[CH:53]=[CH:52][C:39]([CH2:40][C:41]2[CH:51]=[CH:50][CH:49]=[CH:48][C:42]=2[C:43]([O:45][CH2:46][CH3:47])=[O:44])=[CH:38][CH:37]=1>>[CH2:2]([O:9][C:10]1[C:11]([C:24](=[O:25])[NH:26][CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])=[N:12][C:13]([CH2:17][CH:18]2[CH2:19][CH2:20][N:21]([C:36]3[CH:53]=[CH:52][C:39]([CH2:40][C:41]4[CH:51]=[CH:50][CH:49]=[CH:48][C:42]=4[C:43]([O:45][CH2:46][CH3:47])=[O:44])=[CH:38][CH:37]=3)[CH2:22][CH2:23]2)=[N:14][C:15]=1[CH3:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1