Ethyl 2-(4-bromobenzyl)benzoate → Ethyl 2-{4-[4-({5-(benzyloxy)-4-[(2-tert-butoxy-2-oxoethyl)carbamoyl]-6-methylpyrimidin-2-yl}methyl)piperidin-1-yl]benzyl}benzoate

Participants

Reaction Steps

In accordance with Example 1-(9), but using tert-butyl ({[5-(benzyloxy)-6-methyl-2-(piperidin-4-ylmethyl)pyrimidin-4-yl]carbonyl}amino)acetate hydrochloride instead of tert-butyl 5-(benzyloxy)-6-methyl-2-(piperidin-4-ylmethyl)pyrimidine-4-carboxylate hydrochloride, and ethyl 2-(4-bromobenzyl)benzoate instead of [(4′-bromobiphenyl-4-yl)methoxy](tert-butyl)dimethylsilane, the title compound (yield 72%) was afforded as a white solid.

Provenance & Evidence