5-Bromo-2-iodotoluene → HCID 68193177, compound

HRID 1626813Notes

Reaction equation

HRID 1626813 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.[Br:12][C:13]1[CH:18]=[CH:17][C:16](I)=[C:15]([CH3:20])[CH:14]=1>>[Br:12][C:13]1[CH:18]=[CH:17][C:16]([C:6]2[CH:7]=[CH:8][C:3]([CH2:2][OH:1])=[CH:4][CH:5]=2)=[C:15]([CH3:20])[CH:14]=1

Participants

3

Reactant 2

HCID 27246015-Bromo-2-iodotolueneHCID 27347064-(Hydroxymethyl)benzeneboronic acid

Product 1

HCID 68193177HCID 68193177, compoundYield 7.1%

Procedure

In accordance with Example 4-(2), but using [4-(hydroxymethyl)phenyl]boronic acid instead of (4-bromophenyl)boronic acid, and 4-bromo-1-iodo-2-methylbenzene instead of tert-butyl[2-(4-iodophenyl)ethoxy]dimethylsilane, the title compound (yield 7.1%) was afforded as a yellow oil.

Sources & evidence

ORD record
ord-2dcc654203b646679d9192c90dbb475b
Source dataset
uspto-grants-2014_07
Patent number
US08785462B2

Reaction notes

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