1-Bromo-4-iodobenzene → HCID 68193214, compound

HRID 1626816Notes

Reaction equation

HRID 1626816 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12].[Br:13][C:14]1[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=1>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=2[CH3:12])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 115221-Bromo-4-iodobenzeneHCID 3294148Methyl 4-bromo-3-methylbenzoate

Product 1

HCID 68193214HCID 68193214, compoundYield 23%

Procedure

In accordance with Example 19-(2), but using methyl 4-bromo-3-methylbenzoate instead of tert-Butyl 5-(benzyloxy)-2-{[1-(5-bromopyridin-2-yl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate, and 1-bromo-4-iodobenzene instead of tert-butyl[(4-iodobenzyl)oxy]dimethylsilane, the title compound (yield 23%) was afforded as a white solid.

Sources & evidence

ORD record
ord-2e20adcc2caa415ba3f4e30668feaf08
Source dataset
uspto-grants-2014_07
Patent number
US08785462B2

Reaction notes

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