HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66740999, compound → HCID 66740953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66740999 | HCID 66740999 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | HCID 66740953 | HCID 66740953 | 50.6% |
Reaction Steps
A solution of 2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)-propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole (785 mg, 1.13 mmol) in CH3CN was treated with 5% HF in CH3CN/H2O (8:2) and purified by chromatography to afford the title compound (330 mg, 50%) as a white solid. MS (EI) m/z 577.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785488B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-8adc1cca8be54afbb81f094e3fdf373d |
| Source note | uspto-grants-2014_07 |