HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178439129, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine-1-carbonitrile | HCID 86662237 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178439129 | HCID 178439129 | 47% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)piperidine-1-carbonitrile, NaN3 (59 mg, 0.9 mmol), and NH4Cl (50 mg, 0.9 mmol) in DMF (2 mL) was heated at 100° C. overnight. The crude product was purified by HPLC (10-99%, MeCN/H2O with 0.05% TFA) to give the title product as a white solid (45 mg, 47%). MS (EI) m/z 530.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785488B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-101dbd55eb66420f9df1d10cfd81e0da |
| Source note | uspto-grants-2014_07 |