反应详情

450 ml of 2N aqueous sodium hydroxide solution was added to a solution of 75.4 g (300 mmol) of 1-[(3-furanylcarbonyl)amino]cyclohexanecarboxylic acid methyl ester in 450 ml of tetrahydrofuran, and the mixture was heated under reflux for 3 hours. After ether was added to the reaction solution to wash it, the aqueous layer was neutralized by concentrated hydrochloric acid and extracted with ethyl acetate. After the obtained organic layer was washed with saturated brine, it was dried with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 68.8 g (97%) of the title compound.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. washto wash it
4. extractionextracted with ethyl acetate
5. washAfter the obtained organic layer was washed with saturated brine, it
6. dry with materialwas dried with anhydrous sodium sulfate
7. distillationThe solvent was distilled off under reduced pressure