反应详情

10 ml of N-methylmorpholine was added to 1.0 g (9.1 mmol) of L-valine and 2.0 g (9.1 mmol) of 2-(2-furanyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one, and the mixture was stirred and heated under reflux overnight. The reaction solution was distilled off under reduced pressure, ethyl acetate was added thereto, and the mixture was washed with a 10% aqueous potassium hydrogensulfate solution and then saturated brine, followed by drying with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and it was purified by silica gel chromatography to obtain 384 mg (12.5%) of the title compound.

1. temperatureheated
2. temperatureunder reflux overnight
3. distillationThe reaction solution was distilled off under reduced pressure, ethyl acetate
4. additionwas added
5. washthe mixture was washed with a 10% aqueous potassium hydrogensulfate solution
6. dry with materialby drying with anhydrous sodium sulfate
7. distillationThe solvent was distilled off under reduced pressure and it
8. customwas purified by silica gel chromatography