反应详情

Nebivolol free base (3.30 g, 8.70 mmol) is suspended in absolute ethanol (100 mL) and heated to fall until complete dissolution. To this solution, 1.25 M ethanolic HCl (7.5 mL) is added. The obtained solution is concentrated under reduced pressure, until obtaining a 15% concentration of the product. During solvent evaporation, progressive formation of a white precipitate is observed. The solid is filtered by washing with cold absolute ethanol, to obtain 3.10 g of nebivolol hydrochloride salt.

1. temperatureheated
2. dissolutionto fall until complete dissolution
3. concentrationThe obtained solution is concentrated under reduced pressure
4. customuntil obtaining a 15% concentration of the product
5. customDuring solvent evaporation, progressive formation of a white precipitate
6. filtrationThe solid is filtered
7. washby washing with cold absolute ethanol