Hydrochloric Acid → HCID 9933004, compound

HRID 1627755Notes

Reaction equation

HRID 1627755 reaction equation
[CH:1]1[C:6]([F:7])=[CH:5][C:4]2[CH2:8][CH2:9][CH:10]([CH:12]([OH:29])[CH2:13][NH:14][CH2:15][CH:16]([OH:28])[CH:17]3[O:26][C:25]4[CH:24]=[CH:23][C:22]([F:27])=[CH:21][C:20]=4[CH2:19][CH2:18]3)[O:11][C:3]=2[CH:2]=1.[ClH:30]>C(O)C>[CH:23]1[C:22]([F:27])=[CH:21][C:20]2[CH2:19][CH2:18][CH:17]([CH:16]([OH:28])[CH2:15][NH:14][CH2:13][CH:12]([OH:29])[CH:10]3[O:11][C:3]4[CH:2]=[CH:1][C:6]([F:7])=[CH:5][C:4]=4[CH2:8][CH2:9]3)[O:26][C:25]=2[CH:24]=1.[ClH:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71301Nebivolol

Product 1

HCID 9933004HCID 9933004, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Nebivolol free base (3.30 g, 8.70 mmol) is suspended in absolute ethanol (100 mL) and heated to fall until complete dissolution. To this solution, 1.25 M ethanolic HCl (7.5 mL) is added. The obtained solution is concentrated under reduced pressure, until obtaining a 15% concentration of the product. During solvent evaporation, progressive formation of a white precipitate is observed. The solid is filtered by washing with cold absolute ethanol, to obtain 3.10 g of nebivolol hydrochloride salt.

Workup

  1. temperatureheated
  2. dissolutionto fall until complete dissolution
  3. concentrationThe obtained solution is concentrated under reduced pressure
  4. customuntil obtaining a 15% concentration of the product
  5. customDuring solvent evaporation, progressive formation of a white precipitate
  6. filtrationThe solid is filtered
  7. washby washing with cold absolute ethanol

Sources & evidence

ORD record
ord-dffcf1b24b274c6aa9df0c28f49888a7
Source dataset
uspto-grants-2014_07
Patent number
US08785664B2

Reaction notes

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