Methanol → 1-{3-(4-Chloro-phenyl)-1-[2-methoxy-3-(4-o-tolyl-piperazin-1-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-ethanone

HRID 162788Notes

Reaction equation

HRID 162788 reaction equation
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:39][I:40].[CH3:41][OH:42].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][n:10]([CH2:20][CH:21]([CH2:22][N:23]3[CH2:24][CH2:25][N:26]([c:29]4[c:30]([CH3:35])[cH:31][cH:32][cH:33][cH:34]4)[CH2:27][CH2:28]3)[OH:36])[c:11]3[c:12]2[CH2:13][N:14]([C:17]([CH3:18])=[O:19])[CH2:15][CH2:16]3)[cH:6][cH:7]1.[Cl:43][CH2:44][Cl:45].[H-:38].[Na+:37]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][n:10]([CH2:20][CH:21]([CH2:22][N:23]3[CH2:24][CH2:25][N:26]([c:29]4[c:30]([CH3:35])[cH:31][cH:32][cH:33][cH:34]4)[CH2:27][CH2:28]3)[O:36][CH3:44])[c:11]3[c:12]2[CH2:13][N:14]([C:17]([CH3:18])=[O:19])[CH2:15][CH2:16]3)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 6328Methyl iodideHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 166653HydrideHCID 101421501-{3-(4-Chloro-phenyl)-1-[2-hydroxy-3-(4-o-tolyl-piperazin-1-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-ethanone

Product 1

HCID 102796971-{3-(4-Chloro-phenyl)-1-[2-methoxy-3-(4-o-tolyl-piperazin-1-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-ethanone

Sources & evidence

ORD record
ord-a31395ccb0e544edb04b084876edeafa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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