Trimethyl phosphite → HCID 49806461, compound

HRID 1627933Notes

Reaction equation

HRID 1627933 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[S:8][C:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:5]2=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[C:3]=1[CH2:22]Br.[CH3:24][O:25][P:26]([O:29]C)[O:27][CH3:28]>>[CH3:1][C:2]1[N:7]=[C:6]2[S:8][C:9]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:5]2=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[C:3]=1[CH2:22][P:26](=[O:29])([O:27][CH3:28])[O:25][CH3:24]

Participants

3

Reactant 2

HCID 8472Trimethyl phosphiteHCID 66603538HCID 66603538, compound

Product 1

HCID 49806461HCID 49806461, compound

Procedure

A solution of (2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl)bromomethane (0.309 g; 0.8 mmol) in trimethylphosphite (8 mL) was heated at reflux for 18 h. The volatiles were removed under reduced pressure and the remaining residue was used in the next step without further purification.

Workup

  1. temperatureat reflux for 18 h
  2. customThe volatiles were removed under reduced pressure
  3. customthe remaining residue was used in the next step without further purification

Sources & evidence

ORD record
ord-1db72f93907e4a31972933bf24913191
Source dataset
uspto-grants-2014_07
Patent number
US08785638B2

Reaction notes

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