Ammonia → HCID 71471291, compound

HRID 1628213Notes

Reaction equation

HRID 1628213 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][N:14]=1)[C:5]([NH:7][NH:8][C:9]([NH2:11])=[S:10])=O.N>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[S:10][C:9]([NH2:11])=[N:8][N:7]=2)[CH:12]=[CH:13][N:14]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 71471186HCID 71471186, compound

Product 1

HCID 71471291HCID 71471291, compoundYield 93%

Procedure

To a flask was weighed 42 g of PPA. Preheated the flask to 100° C. and then 2.4 g (10 mmol) of 8.1.B were added in portions into the flask. After an hour, ice water was added to dilute the reaction and the pH was adjusted to 7 with aqueous NH3. Bright yellow precipitates were generated. Filtered and the precipitates were dried. LC/MS of the precipitates showed to be the product. 2.05 g of 8.1.C was generated with a yield of 93%.

Workup

  1. customTo a flask was weighed
  2. waitAfter an hour
  3. additionto dilute
  4. customthe reaction
  5. customBright yellow precipitates
  6. filtrationFiltered
  7. customthe precipitates were dried

Sources & evidence

ORD record
ord-6df8166a003544b692cca3a78d542c86
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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