HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(2-Chloropyridin-4-YL)-1,3,4-thiadiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 71471186 | HCID 71471186 | — |
| Product | 5-(2-Chloropyridin-4-YL)-1,3,4-thiadiazol-2-amine | HCID 71471291 | 93% |
Reaction Steps
To a flask was weighed 42 g of PPA. Preheated the flask to 100° C. and then 2.4 g (10 mmol) of 8.1.B were added in portions into the flask. After an hour, ice water was added to dilute the reaction and the pH was adjusted to 7 with aqueous NH3. Bright yellow precipitates were generated. Filtered and the precipitates were dried. LC/MS of the precipitates showed to be the product. 2.05 g of 8.1.C was generated with a yield of 93%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785468B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-6df8166a003544b692cca3a78d542c86 |
| Source note | uspto-grants-2014_07 |