Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5-(2-Chloropyridin-4-YL)-1,3,4-thiadiazol-2-amine | HCID 71471291 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67497358 | HCID 67497358 | 47% |
Reaction Steps
To 5-(2-chloropyridin-4-yl)-1,3,4-thiadiazol-2-amine 8.1.C (1.03 g, 4843 μmol) in a pressure tube was added 16 mL of methylamine 40% in water. The reaction was heated at 130° C. for 3 hours. The pressure tube was cooled down and precipitates were generated. The precipitates were filtered and rinsed with water and dried to afford 476 mg of product 8.1.D (47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08785468B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-a07c96a44c5a45be88e46bc84b1bef91 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
