Methylamine → HCID 67497358, compound

HRID 1628214Notes

Reaction equation

HRID 1628214 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[S:12][C:11]([NH2:13])=[N:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.[CH3:14][NH2:15]>O>[NH2:13][C:11]1[S:12][C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:15][CH3:14])[CH:7]=2)=[N:9][N:10]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 71471291HCID 71471291, compound

Product 1

HCID 67497358HCID 67497358, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

To 5-(2-chloropyridin-4-yl)-1,3,4-thiadiazol-2-amine 8.1.C (1.03 g, 4843 μmol) in a pressure tube was added 16 mL of methylamine 40% in water. The reaction was heated at 130° C. for 3 hours. The pressure tube was cooled down and precipitates were generated. The precipitates were filtered and rinsed with water and dried to afford 476 mg of product 8.1.D (47%).

Workup

  1. temperatureThe pressure tube was cooled down
  2. customprecipitates
  3. filtrationThe precipitates were filtered
  4. washrinsed with water
  5. customdried

Sources & evidence

ORD record
ord-a07c96a44c5a45be88e46bc84b1bef91
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

Loading…