Methylamine → HCID 67497110, compound

HRID 1628216Notes

Reaction equation

HRID 1628216 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[CH3:15][NH2:16]>O1CCOCC1>[NH2:13][C:11]1[N:10]([CH3:14])[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:16][CH3:15])[N:7]=2)[CH:12]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86664821HCID 86664821, compound2×

Product 1

HCID 67497110HCID 67497110, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

The reaction mixture of 3-(2-chloropyrimidin-4-yl)-1-methyl-1H-pyrazol-5-amine, 9.C (74.0 mg, 353.0 μmol) and methanamine (394.7 mg, 1.0 ml, 40% in water, 1.27 mmol) in 1,4-dioxane (1.5 ml) in a seal tube was heated at 50° C. for 7 h. LCMS results showed the reaction was done. The solvent was removed. The crude product was used for next step. MS ESI (pos.) m/e: 205.0 (M+H)+.

Workup

  1. customLCMS results
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-537055be1329440c877f4705b7bdba27
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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