HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 67496741, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(4-Pyridyl)aniline | HCID 459523 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Product | HCID 67496741 | HCID 67496741 | — |
Reaction Steps
To a 100 ml flask was added 3-(pyridin-4-yl)benzenamine 34.1.C. (500 mg, 2.9 mole), HBTU (1300 mg, 3.5 mmole), n-(tert-butoxycarbonyl)-1-phenylalanine (858 g, 3.2 mmole), 20 ml of DMF and DIEA (756 ul, 4.35 mmole). The reaction was stirred at room temperature for 6 hours, at which time the crude reaction was purified with a silica gel column (eluting with 10% MeOH in DCM) to give (S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)phenyl)propanamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785468B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-95838aff0faa4f699a1f4c945b19f793 |
| Source note | uspto-grants-2014_07 |