反应详情

To a 100 ml flask was added 3-(pyridin-4-yl)benzenamine 34.1.C. (500 mg, 2.9 mole), HBTU (1300 mg, 3.5 mmole), n-(tert-butoxycarbonyl)-1-phenylalanine (858 g, 3.2 mmole), 20 ml of DMF and DIEA (756 ul, 4.35 mmole). The reaction was stirred at room temperature for 6 hours, at which time the crude reaction was purified with a silica gel column (eluting with 10% MeOH in DCM) to give (S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)phenyl)propanamide.

1. customreaction
2. customwas purified with a silica gel column (eluting with 10% MeOH in DCM)