HCID 67497457, compound → HCID 135755464, compound

HRID 1628314Notes

Reaction equation

HRID 1628314 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)=[CH:11][C:10]=1[N+:22]([O-])=O)C1C=CC=CC=1>CCOC(C)=O.[Pd]>[NH2:22][C:10]1[CH:11]=[C:12]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)[CH:13]=[CH:14][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 67497457HCID 67497457, compound

Product 1

HCID 135755464HCID 135755464, compoundYield 115.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Nitroarene 64.A (2.65 g, 8 mmol) was hydrogenated (10 psi) with Pd/C (500 mg, 10% Pd/C, 50% water) in EtOAc. The reaction mixture was filtered and concentrated to yield crude 64.B (1.85 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-683357285a8d43bcae91f4daa740489d
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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