HCID 67496336, compound → HCID 67496300, compound

HRID 1628319Notes

Reaction equation

HRID 1628319 reaction equation
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[C:8]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)[CH:7]=1.CC1C=C(C2C=C(C=C([N+]([O-])=O)C=2)OCC(OC)=O)C=CN=1.NC1C=C(C=C(C2C=CN=C(C)C=2)C=1)OCC(OC)=O>>[CH3:22][N:2]([CH3:1])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([NH2:12])[CH:9]=[C:8]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 67496336HCID 67496336, compoundHCID 67497718HCID 67497718, compoundHCID 67498223HCID 67498223, compound

Product 1

HCID 67496300HCID 67496300, compoundYield 93.3%

Procedure

This title intermediate was prepared starting from 76.A (694 mg, 2.30 mmol) according the procedure described above for conversion of 65.D to 65.E. The crude product was purified by flash chromatography on silica gel using 0-10% MeOH/CH2Cl2 for elution to provide 76.B as colorless syrup (582 mg, 93%).

Workup

  1. customThe crude product was purified by flash chromatography on silica gel using 0-10% MeOH/CH2Cl2 for elution

Sources & evidence

ORD record
ord-ee73288752a646b995ebd14a0825f79c
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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