Hydrochloric Acid → HCID 67497271, compound

Participants

Reaction Steps

To a 25 ml flask was added ethyl 2-((S)-1-(1-ethyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylamino)acetate 101.1.C (45 mg, 0.11 mmole), and 1 ml of 1,4-dioxane. To the solution, 1 ml of 4N-hydrogen chloride solution in 1,4-dioxane (4 mmol) was added at 0° C. After then, the solvent was removed by rotary evaporation. The crude product was dried under a high vacuum to give 101.1 (54 mg, 100% yield) as colorless amorphous. LCMS ESI (pos.) m/e: 423 (M+H).

Provenance & Evidence