Hydrochloric Acid → HCID 67497271, compound

HRID 1628337Notes

Reaction equation

HRID 1628337 reaction equation
[CH2:1]([N:3]1[C:7]([NH:8][C:9](=[O:25])[C@@H:10]([NH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:6][C:5]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)=[N:4]1)[CH3:2].[ClH:32]>O1CCOCC1>[ClH:32].[ClH:32].[CH2:1]([N:3]1[C:7]([NH:8][C:9](=[O:25])[C@@H:10]([NH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:6][C:5]([C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)=[N:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67497272HCID 67497272, compound

Product 1

HCID 67497271HCID 67497271, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a 25 ml flask was added ethyl 2-((S)-1-(1-ethyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylamino)acetate 101.1.C (45 mg, 0.11 mmole), and 1 ml of 1,4-dioxane. To the solution, 1 ml of 4N-hydrogen chloride solution in 1,4-dioxane (4 mmol) was added at 0° C. After then, the solvent was removed by rotary evaporation. The crude product was dried under a high vacuum to give 101.1 (54 mg, 100% yield) as colorless amorphous. LCMS ESI (pos.) m/e: 423 (M+H).

Workup

  1. customAfter then, the solvent was removed by rotary evaporation
  2. dry with materialThe crude product was dried under a high vacuum

Sources & evidence

ORD record
ord-b33cc68107a84f52995779a5f8746773
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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